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N Hozumi, S Tonegawa. PMID: 824647. PMCID: PMC431171. DOI: 10.1073/pnas.73.10.3628. Abstract. A high-molecular-weight DNA from Balb/c mouse early embryo or from MOPC 321 …
SOMATIC GENERATION OF IMMUNE DIVERSITY. Nobel lecture, December 8, 1987. by. SUSUMU TONEGAWA. Center for Cancer Research and Department of Biology, …
Using new techniques, Tonegawa and Nobumichi Hozumi tested the latter theory. They used cloned DNA from myeloma cells and DNA from mouse embryo and found that, in the embryonic DNA, the constant and …
N Hozumi 1 , S Tonegawa. Affiliation. 1 Basel Institute for Immunology, Switzerland. PMID: 15383553. Publication types. Biography. Classical Article. Historical Article. MeSH …
The generation of antibody diversity was a problem awaiting the development of powerful molecular techniques. Tonegawa went on to clone V-region genes and prove that the rearrangement must occur somatically. These findings affected …
In 1976, a key paper by Hozumi and Tonegawa provided experimental evidence for the somatic rearrange-ment of immunoglobulin genes.
the Hozumi and Tonegawa experiment (Tonegawa et al., 1977a). This marked the beginning of a series of truly exciting discoveries that came out of our collaboration during the subsequent …